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KMID : 1141520220370030387
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Endocrinology and Metabolism
2022 Volume.37 No. 3 p.387 ~ p.392
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Euthyroid Thyroperoxidase Antibody Positivity during Pregnancy, to Treat or Not to Treat?
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Korevaar Tim I. M.
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Abstract
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Thyroperoxidase antibody (TPOAb) positivity is a well-known risk factor for thyroid dysfunction during pregnancy and is associated with a suboptimal response to thyroidal stimulation by human chorionic gonadotropin. About 75% of TPOAb positive women are euthyroid and there seems to be a higher risk of predominantly miscarriage and preterm birth in this subgroup. Nonetheless, clinical decision making with regards to gestational levothyroxine treatment remains difficult due to a lack of large randomized trials. Future studies assessing dose-dependent associations and additional biomarkers that can distinguish low-risk from high-risk individuals will be key in disentangling the crude clinical data.
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KEYWORD
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Pregnancy, Thyroid gland, Thyroperoxidase antibodies
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